南京大學醫學院附屬鼓樓醫院科研團隊發現，骨質疏松會加劇認知功能衰退，為臨床上治療阿爾茨海默癥等神經退行性疾病提供了新思路。相關論文近期發表于國際學術期刊《自然·代謝》。

老年增齡和阿爾茨海默病進展中，骨組織中骨細胞特異性分泌的骨硬化蛋白通過血-腦屏障，抑制中樞神經元Wnt通路而上調BACE1的表達。課題組供圖

Chinese researchers have discovered that osteoporosis may impair cognitive function, providing a new approach for the clinical treatment of neurodegenerative disorders such as Alzheimer's disease, according to the Nanjing University.南京大學表示，我國學者發現骨質疏松會加劇認知功能衰退，為臨床上治療阿爾茨海默癥等神經退行性疾病提供了新思路。

The discovery, made by a research team from the Nanjing Drum Tower Hospital affiliated with the Medical School of the Nanjing University, has been published in the journal Nature Metabolism.相關論文由南京大學醫學院附屬鼓樓醫院科研團隊發表于國際學術期刊《自然·代謝》上。

Previous research has shown that the bones of elderly patients with osteoporosis would release a key osteocyte-derived factor called sclerostin, said Jiang Qing, associate dean at the Medical School of the Nanjing University, adding that in the patient's blood and cerebrospinal fluid, the proportion of sclerostin are high.南京大學醫學院副院長蔣青表示，此前有研究顯示，骨質疏松的老年患者，其骨骼會釋放一種骨硬化蛋白。在患者的血液和腦脊液當中，骨硬化蛋白的比例均偏高。

The team have conducted more than six years of research on the intrinsic connection between sclerostin and the brain.骨硬化蛋白和大腦之間有什么內在聯系？對此團隊開展了為期6年多的研究。

Mouse experiments show that sclerostin released by bone cells of aged mice can break through the blood-brain barrier, inhibit the signal transmission of central neurons, damage the plasticity and integrity of neuronal synapses, and cause a decline in the cognitive functions in mice, said Guo Baosheng, associate professor at the medical school.南京大學醫學院郭保生副教授介紹，小鼠實驗顯示，老年小鼠骨細胞分泌的骨硬化蛋白可以突破“血腦屏障”，抑制中樞神經元的信號傳遞，損傷神經元突觸的可塑性和完整性，從而導致小鼠認知功能衰退。

In addition, in the Alzheimer's mouse model experiment, the researchers found that increasing the concentration of sclerostin could accelerate the formation of amyloid plaque and further exacerbate cognitive decline.另外，在阿爾茨海默癥小鼠模型實驗中，研究人員發現，增加骨硬化蛋白濃度，淀粉樣斑塊形成速度加快，患病小鼠的認知功能也進一步惡化。

The research findings demonstrated that Alzheimer's patients with osteoporosis are at an increased risk of cognitive impairment, Guo said.郭保生說，研究結果表明，患有骨質疏松癥的阿爾茨海默癥患者病情進一步加重的風險增加。

英文來源：新華網

編輯：董靜

審核：丹妮 齊磊

來源：中國日報網